1-叔丁氧羰基-2-甲基-哌啶酮合成路线 （共 9 条）
反应条件
sodium hydrogencarbonate in chloroform; water
反应条件
toluene-4-sulfonic acid in acetone T=0 - 20°C;
参考文献
EP1375482 A1, ;
Page 153 ;
反应条件
hydrogen; palladium hydroxide on carbon in ethyl acetate T=20°C; 2 h;
参考文献
WO2008/45250 A1, ;
Page/Page column 29 ;
WO 2008/045250 A1
反应条件
1: 4-methoxy pyridine With phenyl chloroformate in tetrahydrofuran T=-40°C; 0.25 h; 2: methyl-magnesium chloride in tetrahydrofuran T=-40 - 20°C; 0.5 h; 3: potassium tert-butylate With oxalic acid more than 3 stages;
参考文献
EP1204660 B1, ;
Page 17 ;
反应条件
1: With potassium tert-butylate in tetrahydrofuran T=0 - 20°C; 5.5 h; 2: With hydrogenchloride in water 14.5 h; Heating / reflux; 3: With sodium hydroxide in tetrahydrofuran; water T=0°C;
参考文献
US2003/225281 A1, ;
Page 14-15 ;
反应条件
sodium hydroxide in tetrahydrofuran; water T=20°C; pH=8 - 9; 96 h;
参考文献
US2003/232833 A1, ;
Page 15 ;
反应条件
sodium hydroxide in water T=20°C; Product distribution / selectivity;
参考文献
WO2006/24517 A1, ;
Page/Page column 104 ;
WO 2006/024517 A1
反应条件
Resolution of racemate;
参考文献
ELI LILLY AND COMPANY
Patent: WO2004/94380 A1, 2004 ;
Location in patent: Page 26-27 ;
WO 2004/094380 A1
反应条件
1: With sodium tetrahydroborate in methanol
T=20°C; 1 h;
2: With methanol; water
T=20°C; 1 h;
参考文献
METABOLEX, INC.
Patent: WO2009/14910 A2, 2009 ;
Location in patent: Page/Page column 120-121 ;
WO 2009/014910 A2
