1.1: oxalyl dichloride / N,N-dimethyl-formamide / 5 h / 25 - 30 °C 1.2: 6 h / 20 - 30 °C 2.1: potassium tert-butylate / tetrahydrofuran / 4 h / 16 - 25 °C 2.2: 1.83 h / 20 - 21 °C 3.1: AlCl3, aluminium chloride; 1,1,3,3-tetramethyldisiloxane / toluene / 2.5 h / 18 - 26 °C 4.1: isopropylmagnesium chloride; lithium chloride / tetrahydrofuran / 1.83 h / -21 - -15 °C 4.2: 2.92 h / -25 - -13 °C View Scheme

hydrogenchloride T=20°C; 48 h;

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 16.17 h / 10 - 25 °C 2.1: AlCl3, aluminium chloride / dichloromethane / 0.5 h / -3 - 5 °C 2.2: 12 h / 0 - 25 °C 2.3: polymethylhydrosiloxane (PMHS) / 16 h / 30 °C 3.1: isopropylmagnesium chloride lithium chloride complex / tetrahydrofuran / 1.5 h / -5 - 0 °C / |Inert atmosphere 3.2: 1 h / -5 - 0 °C 3.3: 16 h / -10 - 20 °C 4.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / 0.33 h / -20 - 20 °C / |Inert atmosphere View Scheme

palladium diacetate; sodium carbonate in water T=50°C; 2 h; Inert atmosphere;