1-(2-苯基乙基)-2-哌嗪酮合成路线 （共 4 条）
反应条件
trifluoroacetic acid in ethanol; dichloromethane
参考文献
Merck Sharp and Dohme Ltd.
Patent: US5998415 A1, 1999 ;
US 5998415 A
反应条件
1: 30 percent / K2CO3 / dimethylformamide / 4 h / 60 °C 2: 79 percent / Et3N / CH2Cl2 / 0.5 h / -10 °C 3: CH2Cl2 / 1 h / Ambient temperature 4: K2CO3 / ethanol / 20 h / Heating View Scheme
参考文献
Chambers, Mark S.; Street, Leslie J.; Goodacre, Simon; Hobbs, Sarah C.; Hunt, Peter; Jelley, Richard A.; Matassa, Victor G.; Reeve, Austin J.; Sternfeld, Francine; Beer, Margaret S.; Stanton, Josephine A.; Rathbone, Denise; Watt, Alan P.; MacLeod, Angus M.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 691 - 705
反应条件
1: 79 percent / Et3N / CH2Cl2 / 0.5 h / -10 °C 2: CH2Cl2 / 1 h / Ambient temperature 3: K2CO3 / ethanol / 20 h / Heating View Scheme
参考文献
Chambers, Mark S.; Street, Leslie J.; Goodacre, Simon; Hobbs, Sarah C.; Hunt, Peter; Jelley, Richard A.; Matassa, Victor G.; Reeve, Austin J.; Sternfeld, Francine; Beer, Margaret S.; Stanton, Josephine A.; Rathbone, Denise; Watt, Alan P.; MacLeod, Angus M.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 691 - 705
反应条件
1: CH2Cl2 / 1 h / Ambient temperature 2: K2CO3 / ethanol / 20 h / Heating View Scheme
参考文献
Chambers, Mark S.; Street, Leslie J.; Goodacre, Simon; Hobbs, Sarah C.; Hunt, Peter; Jelley, Richard A.; Matassa, Victor G.; Reeve, Austin J.; Sternfeld, Francine; Beer, Margaret S.; Stanton, Josephine A.; Rathbone, Denise; Watt, Alan P.; MacLeod, Angus M.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 4 p. 691 - 705
