1-Cbz-4-哌啶酮合成路线

参考文献

Borisov, Alexander V.; Voloshchuk, Volodymyr V.; Nechayev, Maxim A.; Grygorenko, Oleksandr O.
Synthesis (Germany), 2013 , vol. 45, # 17 art. no. SS-2013-Z0293-OP, p. 2413 - 2416

19099-93-51-Cbz-4-哌啶酮+

676-58-4甲基氯化镁

169750-57-64-羟基-4-甲基哌啶-1-羧酸苄酯

参考文献

Takeda Pharmaceutical Company Limited
Patent: EP2392573 A1, 2011 ;
Location in patent: Page/Page column 40 ;

19099-93-51-Cbz-4-哌啶酮+

917-54-4甲基锂

169750-57-64-羟基-4-甲基哌啶-1-羧酸苄酯

参考文献

Eisai Co., Ltd.
Patent: EP1522540 A1, 2005 ;
Location in patent: Page/Page column 53 ;
EP 1522540 A1

19099-93-51-Cbz-4-哌啶酮

1355171-29-7

参考文献

Petersen, Jette G.; Bergmann, Rikke; Moller, Henriette A.; Jorgensen, Charlotte G.; Nielsen, Birgitte; Kehler, Jan; Frydenvang, Karla; Kristensen, Jesper; Balle, Thomas; Jensen, Anders A.; Kristiansen, Uffe; Frolund, Bente
Journal of Medicinal Chemistry, 2013 , vol. 56, # 3 p. 993 - 1006

109-04-6邻溴吡啶+

19099-93-51-Cbz-4-哌啶酮

161610-16-8苄基4-羟基-4-(2-吡啶基)-1-哌啶羧酸酯

参考文献

Stewart, Andrew O.; Kolasa, Teodozyj
Patent: US2003/232836 A1, 2003 ;
Location in patent: Page 49 ;
US 20030232836 A1

19099-93-51-Cbz-4-哌啶酮

161610-16-8苄基4-羟基-4-(2-吡啶基)-1-哌啶羧酸酯

参考文献

Bhatia, Pramila A.; Daanen, Jerome F.; Hakeem, Ahmed A.; Kolasa, Teodozyj; Matulenko, Mark A.; Mortell, Kathleen H.; Patel, Meena V.; Stewart, Andrew O.; Wang, Xueqing; Xia, Zhiren; Zhang, Henry Q.
Patent: US2003/229094 A1, 2003 ;
Location in patent: Page 73 ;
US 20030229094 A1

109-04-6邻溴吡啶+

19099-93-51-Cbz-4-哌啶酮

161610-16-8苄基4-羟基-4-(2-吡啶基)-1-哌啶羧酸酯

参考文献

Zeneca Limited
Patent: US5654299 A1, 1997 ;

19099-93-51-Cbz-4-哌啶酮

185847-84-14-氧代-3,4-二氢吡啶-1(2H)-羧酸苄酯

参考文献

Ye, Xiaocong M.; Konradi, Andrei W.; Smith, Jenifer; Xu, Ying-Zi; Dressen, Darren; Garofalo, Albert W.; Marugg, Jennifer; Sham, Hing L.; Truong, Anh P.; Jagodzinski, Jacek; Pleiss, Michael; Zhang, Hongbin; Goldbach, Erich; Sauer, John-Michael; Brigham, Elizabeth; Bova, Michael; Basi, Guriqbal S.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 7 p. 2195 - 2199

19099-93-51-Cbz-4-哌啶酮

177-11-74-哌啶酮缩乙二醇

参考文献

Journal of Medicinal Chemistry, , vol. 35, # 8 p. 1393 - 1398

75-77-4三甲基氯硅烷+

19099-93-51-Cbz-4-哌啶酮

1147998-34-24-(三甲基硅基氧基)-5,6-二氢吡啶-1(2H)-甲酸苄酯

参考文献

WO2013/177253 A2, ;

Page/Page column 74; 75 ;