反应条件
1: 60 percent / lithium hexamethyldisilazide / tetrahydrofuran / 4 h / -78 °C
2: 78 percent / potassium acetate; [1,1'-bis(diphenylphosphino)ferrocene] dichloropalladium(II); 1,1'-bis(diphenylphosphino)ferrocene / dioxane / 16 h / 80 °C
3: 78 percent / potassium carbonate; [1,1'-bis(diphenylphosphino)ferrocene] dichloropalladium(II) / dimethylformamide / 16 h / 80 °C
4: 30 mg / H2 / Pd/C / ethanol / 24 h / 23 °C
View Scheme
参考文献
Patel, Meena V.; Kolasa, Teodozyj; Mortell, Kathleen; Matulenko, Mark A.; Hakeem, Ahmed A.; Rohde, Jeffrey J.; Nelson, Sherry L.; Cowart, Marlon D.; Nakane, Masaki; Miller, Loan N.; Uchic, Marie E.; Terranova, Marc A.; El-Kouhen, Odile F.; Donnelly-Roberts, Diana L.; Namovic, Marian T.; Hollingsworth, Peter R.; Chang, Renjie; Martino, Brenda R.; Wetter, Jill M.; Marsh, Kennan C.; Martin, Ruth; Darbyshire, John F.; Gintant, Gary; Hsieh, Gin C.; Moreland, Robert B.; Sullivan, James P.; Brioni, Jorge D.; Stewart, Andrew O.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7450 - 7465