反应条件
1: 2-(2-tert-butyldimethylsiloxyethyl)-4H-benzo[1,4]oxazin-3-one With sodium hydride in N,N-dimethyl-formamide
T=0°C; 0.5 h;
2: methyl iodide in N,N-dimethyl-formamide
T=0 - 20°C;
3: With methanesulfonic acid in methanol
T=20°C; 0.5 h;
参考文献
Rybczynski, Philip J.; Zeck, Roxanne E.; Dudash Jr., Joseph; Combs, Donald W.; Burris, Thomas P.; Yang, Maria; Osborne, Melville C.; Chen, Xiaoli; Demarest, Keith T.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 1 p. 196 - 209
