1'-羟基-2',3'-去氢草蒿脑合成路线 （共 29 条）
反应条件
1: 4-(N,N-dimethlyamino)pyridine / acetonitrile / 4 h / 0 °C / |Inert atmosphere 2: potassium carbonate; [RhCl(PPh3)3]; phosphorous acid trimethyl ester / tetrahydrofuran / 24 h / 30 °C / |Inert atmosphere 3: potassium tert-butylate / tetrahydrofuran / 20 °C / |Inert atmosphere 4: silver hexafluoroantimonate; C27H37AuClN2 / 1,2-dichloro-ethane / 19 h / 40 °C / |Inert atmosphere View Scheme
参考文献
Ma, Zhi-Xiong; He, Shuzhong; Song, Wangze; Hsung, Richard P.
Organic Letters, 2012 , vol. 14, # 22 p. 5736 - 5739
反应条件
[bis(trifluoromethanesulfonyl)imidate](PPh3)Au(I) (2:1) toluene adduct in methanol; toluene T=20°C; Meyer-Schuster rearrangement; 12 h;
参考文献
Pennell, Matthew N.; Turner, Peter G.; Sheppard, Tom D.
Chemistry - A European Journal, 2012 , vol. 18, # 15 p. 4748 - 4758
反应条件
1: AgNTf2 / toluene / 12 h / 20 °C 2: [bis(trifluoromethanesulfonyl)imidate](PPh3)Au(I) (2:1) toluene adduct / methanol; toluene / 12 h / 20 °C View Scheme
参考文献
Pennell, Matthew N.; Turner, Peter G.; Sheppard, Tom D.
Chemistry - A European Journal, 2012 , vol. 18, # 15 p. 4748 - 4758
反应条件
manganese(IV) oxide; ammonium acetate; acetic acid in toluene Heating;
参考文献
Bagley, Mark C.; Hughes, David D.; Sabo, Halima M.; Taylor, Paul H.; Xiong, Xin
Synlett, 2003 , # 10 p. 1443 - 1446
反应条件
acetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in dimethyl sulfoxide Heating;
参考文献
Bagley, Mark C.; Hughes, David D.; Sabo, Halima M.; Taylor, Paul H.; Xiong, Xin
Synlett, 2003 , # 10 p. 1443 - 1446
反应条件
trans-[RuCl2(η3:η3-2,7-dimethylocta-2,6-diene-1,8-diyl)(PPh3)] in water T=60°C; 22 h; Sealed tubeInert atmosphere;
参考文献
Cadierno, Victorio; Francos, Javier; Gimeno, Jose
Organometallics, 2011 , vol. 30, # 4 p. 852 - 862
反应条件
1: 83 percent / Pd(PPh3)2Cl2; CuI; Et3N / dimethylformamide / 24 h / 20 °C 2: 70 percent / p-toluenesulfonic acid / benzene / 24 h / 20 °C 3: 61 percent / p-toluenesulfonic acid / benzene / 8 h / Heating View Scheme
参考文献
De, Mahuya; Majumdar, Dyuti P.; Kundu, Nitya G.
Journal of the Indian Chemical Society, 1999 , vol. 76, # 11-12 p. 665 - 674
反应条件
1: 86 percent / hydrogen / Pd/C / ethyl acetate / 48 h / 20 °C View Scheme
参考文献
Melikyan, Gagik G.; Sepanian, Steve; Riahi, Bobby; Villena, Ferdinand; Jerome, John; Ahrens, Brian; McClain, Randolph; Matchett, John; Scanlon, Stephanie; Abrenica, Edwin; Paulsen, Kevin; Hardcastle, Kenneth I.
Journal of Organometallic Chemistry, 2003 , vol. 683, # 2 p. 324 - 330
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / |Inert atmosphere 1.2: 1 h / -78 - -20 °C / |Inert atmosphere 1.3: 1 h / -20 - 20 °C / |Inert atmosphere 2.1: manganese(IV) oxide / acetone / 2 h / 20 °C / |Inert atmosphere 3.1: hydrazine hydrate / ethanol / 2 h / 20 °C / |Inert atmosphere View Scheme
参考文献
Kirkham, James D.; Edeson, Steven J.; Harrity, Joseph P. A.; Stokes, Stephen
Organic Letters, 2012 , vol. 14, # 20 p. 5354 - 5357,4
反应条件
copper(l) iodide; tetra(n-butyl)ammonium hydroxide; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran; water T=80°C; Sonogashira coupling; 24 h;
参考文献
Cho, Chan Sik
Journal of Organometallic Chemistry, 2005 , vol. 690, # 17 p. 4094 - 4097
