2-甲基-4,6-二苯基吡啶合成路线 (共 15 条)
反应条件
potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether; ethanol; water
T=90°C; 2 h;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2008/44217 A2, 2008 ;
Location in patent: Page/Page column 84 ;
WO 2008/044217 A2
反应条件
palladium on activated charcoal in ethanol
参考文献
Harris, D. J.; Kan, G. Y.-P.; Tschamber, T.; Snieckus, V.
Canadian Journal of Chemistry, 1980 , vol. 58, p. 494 - 500
反应条件
copper(l) iodide in dimethyl sulfoxide
T=60°C; 16 h; Inert atmosphereSchlenk techniqueSealed tube;
参考文献
Wei, Ye; Yoshikai, Naohiko
Journal of the American Chemical Society, 2013 , vol. 135, # 10 p. 3756 - 3759
反应条件
C45H59CoFeN4Si2
T=100°C; 24 h; Inert atmosphere;
参考文献
Wang, Wenyuan; Inoue, Shigeyoshi; Enthaler, Stephan; Driess, Matthias
Angewandte Chemie - International Edition, 2012 , vol. 51, # 25 p. 6167 - 6171
反应条件
1: 97 percent / 5percent Yb(fod)3 / CH2Cl2 / Heating
2: 85 percent / NH2OH*HCl / ethanol / 10 h / Heating
View Scheme
参考文献
Ciufolini, Marco A.; Byrne, Norman E.
Journal of the Chemical Society, Chemical Communications, 1988 , # 18 p. 1230 - 1231
反应条件
n-butyllithium; CuSPh; acetic acid
1.) THF, hexane, -78 deg C, 2.) -70 deg C, 12 h, 3.) -78 deg C, to RT, then reflux 4 h; Yield given. Multistep reaction;
参考文献
Kelly, T. Ross; Liu, Hshiou-ting
Journal of the American Chemical Society, 1985 , vol. 107, # 17 p. 4998 - 4999
反应条件
sodium hydroxide in 2-ethoxy-ethanol
4 h; Heating;
参考文献
Shibata, Katsuyoshi; Katsuyama, Isamu; Izoe, Hideaki; Matsui, Masaki; Muramatsu, Hiroshige
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 1 p. 277 - 281
反应条件
(.eta.3-allyl)(.eta.5-pentamethylcyclopentadienyl)cobalt in hexane
T=20°C; 72 h; Yield given. Yields of byproduct given;
参考文献
Nehl, Hans
Chemische Berichte, 1994 , vol. 127, # 12 p. 2535 - 2538
反应条件
in benzene
24 h; Heating;
参考文献
Kobayashi, Tomoshige; Nitta, Makoto
Chemistry Letters, 1986 , p. 1549 - 1552
反应条件
in benzene
24 h; Heating;
参考文献
Kobayashi, Tomoshige; Nitta, Makoto
Chemistry Letters, 1986 , p. 1549 - 1552