[(1S,2R)-1-苄基-2-羟基-3-[异丁基[(4-硝基苯基)磺酰]氨基]丙基]氨基甲酸叔丁酯合成路线 （共 23 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol T=22 - 30°C; Product distribution / selectivity;
参考文献
TIBOTEC PHARMACEUTICALS LTD.
Patent: WO2005/63770 A1, 2005 ;
Location in patent: Page/Page column 27 ;
WO 2005/063770 A1
反应条件
1: With triethanolamine; hydrogen; palladium 10 on activated carbon in methanol T=40 - 45°C; 2 h; 2: With hydrogenchloride; water 2 h; Reflux; 3: With sodium hydroxide in water; isopropyl alcohol T=20°C; pH=9 - 10; 10 h;
参考文献
MATRIX LABORATORIES LIMITED; VELLANKI, Siva Rama Prasad; SAHU, Arabinda; KATUKURI, Aravind Kumar; VANAMA, Vikram; KOTHARI, Satishbabu; PONNEKANTI, Venkata Suryanarayana; DATTA, Debashish
Patent: WO2011/48604 A2, 2011 ;
Location in patent: Page/Page column 19 ;
反应条件
1: [(1S,2R)-3-[[(4-nitrophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid tert-butyl ester With hydrogenchloride in dichloromethane
1.5 h;
2: (S)-3-tetrahydrofuranyl-N-oxysuccinimidyl carbonate With triethylamine in dichloromethane
T=20°C; 4 h; Further stages.;
参考文献
Kim; Bae; So; Yoo; Chang; Lee; Kang
Organic letters, 2001 , vol. 3, # 15 p. 2349 - 2351
