C63H78IrNOP; hydrogen; caesium carbonate in methanol T=40°C; P=4560.31 Torr; 10 h; AutoclaveInert atmosphere; enantioselective reaction;

hydrogen; (R)-spirofluorene-bis[(4-Me-C6H4)2P]-[Ru(OAc)2] in methanol T=25 - 28°C; P=76000 Torr; 12 h; Title compound not separated from byproducts;

1: K2CO3 / acetonitrile / 16 h / 80 °C 2: KOH / H2O / 20 h / 22 °C 3: Et3N; (S)-synphos; H2 / [(p-cymene)RuCl2]2 / ethanol; methanol; CH2Cl2 / 20 h / 20 - 25 °C / 4654.33 Torr View Scheme

[3H]-Strychnine