(3R,4S)-1-(4-氟苯基)-3-[3-(4-氟苯基)-3-氧代丙基]-4-(4-羟基苯基)氮杂环丁烷-2-酮合成路线 （共 23 条）
反应条件
1: With dimethylsulfide borane complex; (R)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c]-[1,3,2]oxazaborole in dichloromethane T=0 - 5°C; 0.25 h; 2: With water; dihydrogen peroxide in dichloromethane T=0 - 20°C; 0.5 h; Product distribution / selectivity;
参考文献
IND-SWIFT LABORATORIES LIMITED
Patent: WO2008/96372 A2, 2008 ;
Location in patent: Page/Page column 22 ;
反应条件
hydrogen; palladium 10 on activated carbon in ethanol P=3102.97 Torr; 16 h;
参考文献
Kyslikova, Eva; Babiak, Peter; Maresova, Helena; Palyzova, Andrea; Hajicek, Josef; Kyslik, Pavel
Journal of Molecular Catalysis B: Enzymatic, 2010 , vol. 67, # 3-4 p. 266 - 270
反应条件
1: With dimethylsulfide borane complex; (R)-tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c]-[1,3,2]oxazaborole in dichloromethane T=0 - 5°C; 0.25 h; 2: With water; dihydrogen peroxide in dichloromethane T=0 - 20°C; 0.5 h; Product distribution / selectivity;
参考文献
IND-SWIFT LABORATORIES LIMITED
Patent: WO2008/96372 A2, 2008 ;
Location in patent: Page/Page column 22 ;
