1: 100 percent / p-toluenesulfonic acid*H2O / benzene / 5 h / Heating 2: 29 percent / H2 / 5percent Pd/C / propan-2-ol / 5 h / 50 °C / 2280 Torr 3: 86 percent / KOH / ethanol / 16 h / Ambient temperature 4: 98 percent / conc. H2SO4 / 16 h / Ambient temperature 5: 100 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C 6: 80 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature 7: 94 percent / NaH / dimethylformamide / 5 h / Ambient temperature 8: 78 percent / 4 N aq. HCl / dioxane / 16 h / Ambient temperature View Scheme

1: 100 percent / p-toluenesulfonic acid*H2O / benzene / 5 h / Heating 2: 29 percent / H2 / 5percent Pd/C / propan-2-ol / 5 h / 50 °C / 2280 Torr 3: 86 percent / KOH / ethanol / 16 h / Ambient temperature 4: 98 percent / conc. H2SO4 / 16 h / Ambient temperature 5: 100 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C 6: 80 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature View Scheme

1: 100 percent / p-toluenesulfonic acid*H2O / benzene / 5 h / Heating 2: 29 percent / H2 / 5percent Pd/C / propan-2-ol / 5 h / 50 °C / 2280 Torr 3: 86 percent / KOH / ethanol / 16 h / Ambient temperature 4: 98 percent / conc. H2SO4 / 16 h / Ambient temperature 5: 100 percent / pyridine / CH2Cl2 / 0.5 h / 0 °C 6: 80 percent / Et3N / CH2Cl2 / 16 h / Ambient temperature 7: 94 percent / NaH / dimethylformamide / 5 h / Ambient temperature 8: 78 percent / 4 N aq. HCl / dioxane / 16 h / Ambient temperature 9: 96 percent / 1 N aq. NaOH / 16 h / Ambient temperature View Scheme

暂无反应条件数据

ethanol; ammonia; palladium Hydrogenation;

[RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; water; hydrogen bromide; hydrogen in tetrahydrofuran T=90°C; P=20686.5 Torr; 20 h; Autoclave; optical yield given as percent eeenantioselective reaction;

hydrogenchloride; [RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; water; hydrogen in tetrahydrofuran T=70°C; P=20686.5 Torr; 20 h; Autoclave; optical yield given as percent eeenantioselective reaction;

hydrogenchloride; [RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; water; hydrogen in tetrahydrofuran T=90°C; P=20686.5 Torr; 10 h; Autoclave; optical yield given as percent eeenantioselective reaction;

1: (E)-2-oxo-4-phenylbut-3-enoic acid With hydrogenchloride; [RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; water; hydrogen in tetrahydrofuran T=70°C; P=20686.5 Torr; 20 h; Autoclave; 2: ethanol With sulfuric acid 5 h; Inert atmosphereReflux; optical yield given as percent eeenantioselective reaction;

1: (E)-2-oxo-4-phenylbut-3-enoic acid With hydrogenchloride; [RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; water; hydrogen in tetrahydrofuran T=90°C; P=20686.5 Torr; 10 h; Autoclave; 2: ethanol With sulfuric acid 5 h; Inert atmosphereReflux; optical yield given as percent eeenantioselective reaction;