反应条件
1: 1.) diisopropylamine, n-BuLi / 1.) THF, hexane, -78 deg C, 0.5 h, 2.) THF, hexane, from -78 deg C to RT
2: thionyl chloride / benzene / 2.5 h / Heating
3: NH3 / dioxane / 2 h / Ambient temperature
4: P2O5 / toluene / 2 h / Heating
5: 1.) NaOCH3 / 1.) CH3OH, 2 h, 2.) CH3OH, 0 - 5 deg C, 0.25 h
View Scheme
参考文献
Chapleo, Christopher B.; Myers, Peter L.; Butler, Richard C. M.; Davis, John A.; Doxey, John C.; et al.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 570 - 576
