(S)-(-)-N-乙酰基-1-甲基苄胺合成路线 （共 50 条）
反应条件
1: (S)-N-acetyl-1-phenylethylamine With triphenyl phosphite; chlorine; triethylamine in dichloromethane T=-30°C; 2: ethylene glycol in dichloromethane T=-30 - 20°C; 3: With water
参考文献
Spaggiari, Alberto; Blaszczak, Larry C.; Prati, Fabio
Organic Letters, 2004 , vol. 6, # 22 p. 3885 - 3888
反应条件
(i) (nitration), (ii) (hydrolysis); Multistep reaction;
参考文献
Cope,A.C. et al.
Journal of the American Chemical Society, 1970 , vol. 92, # 5 p. 1243 - 1247
反应条件
NH4Br; ethylenediamine T=80°C; 10 h; Microwave irradiationInert atmosphereneat (no solvent);
参考文献
Shimizu, Yuhei; Morimoto, Hiroyuki; Zhang, Ming; Ohshima, Takashi
Angewandte Chemie - International Edition, 2012 , vol. 51, # 34 p. 8564 - 8567
反应条件
1: (S)-N-acetyl-1-phenylethylamine With triphenyl phosphite; chlorine; triethylamine in dichloromethane T=-30°C; 2: ethylene glycol in dichloromethane T=-30 - 20°C; 3: With water
参考文献
Spaggiari, Alberto; Blaszczak, Larry C.; Prati, Fabio
Organic Letters, 2004 , vol. 6, # 22 p. 3885 - 3888
反应条件
(i) (nitration), (ii) (hydrolysis); Multistep reaction;
参考文献
Cope,A.C. et al.
Journal of the American Chemical Society, 1970 , vol. 92, # 5 p. 1243 - 1247
反应条件
(S)-diBr-SIPHOS; hydrogen; rhodium(I)-bis(1,5-cyclooctadiene) tetrafluoroborate in toluene
T=0°C; P=38000 Torr; 30 h;
参考文献
Chen, Weiping; Roberts, Stanley M.; Whittall, John
Tetrahedron Letters, 2006 , vol. 47, # 25 p. 4263 - 4266
反应条件
ruthenium(III) 2,4-pentanedionate
T=25°C; 8 h;
参考文献
Varala, Ravi; Nasreen, Aayesha; Adapa, Srinivas R.
Canadian Journal of Chemistry, 2007 , vol. 85, # 2 p. 148 - 152
反应条件
lt;lt;(R,R)-1,2-bis(trans-2,5-dimethylphospholano)ethanegt;Rh(COD)gt;OTf; hydrogen in methanol
T=22°C; P=3102.9 Torr; 15 h; var. rhodium chiral complexes and solvents; other aryl enamides; Product distribution;
参考文献
Burk, Mark J.; Wang, Yan Ming; Lee, Jeffrey R.
Journal of the American Chemical Society, 1996 , vol. 118, # 21 p. 5142 - 5143
反应条件
in dichloromethane
T=20°C; Inert atmosphere;
参考文献
Sultane, Prakash R.; Mete, Trimbak B.; Bhat, Ramakrishna G.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 2 p. 261 - 264
反应条件
oxygen; rose bengal in acetonitrile
T=13°C; 5 h; Irradiation;
参考文献
Gollnick, Klaus; Koegler, Sigrid; Maurer, Dorothee
Journal of Organic Chemistry, 1992 , vol. 57, # 1 p. 229 - 234
