2-羟基-9H-9-氧杂蒽酮合成路线 （共 33 条）
反应条件
1: 79 percent / tBuOK / dimethylformamide / 11 h / 115 °C 2: 1.) NaOH, 2.) HCl / 1.) EtOH, H2O, 25 deg C, 4 h, 2.) H2O, pH 3 3: 1.) NaBH4, NaOH, 2.) NaHCO3 / 1.) H2O, 50-55 deg C, 2.5 h, pH 8.3, 2.) 25 deg, 1 h. View Scheme
参考文献
Han; Bontems; Hegyes; Munson; Minor; Kates; Albericio; Barany
Journal of Organic Chemistry, 1996 , vol. 61, # 18 p. 6326 - 6339
反应条件
potassium carbonate in acetone 15 h; Heating;
参考文献
Somlai, Csaba; Hegyes, Peter; Fenyoe, Robert; Toth, Gabor K.; Penke, Botond; Voelter, Wolfgang
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2001 , vol. 56, # 6 p. 526 - 532
反应条件
1: acetic acid / Erhitzen des Reaktionsgemisches mit wss. Salzsaeure 2: pyridine; aqueous hydrogen peroxide; aqueous NaOH-solution View Scheme
参考文献
Davies et al.
Journal of the Chemical Society, 1958 , p. 1790,1793
反应条件
sulfuric acid
T=100°C; 2 h;
参考文献
Hoppmann, Christian; Alexiev, Ulrike; Irran, Elisabeth; Rueck-Braun, Karola
Tetrahedron Letters, 2013 , vol. 54, # 34 p. 4585 - 4587
反应条件
2,6-dimethylpyridine; lithium iodide
48 h; Heating;
参考文献
Somlai, Csaba; Hegyes, Peter; Fenyoe, Robert; Toth, Gabor K.; Penke, Botond; Voelter, Wolfgang
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2001 , vol. 56, # 6 p. 526 - 532
反应条件
pyridine hydrochloride
T=210°C; 10 h;
参考文献
Han; Bontems; Hegyes; Munson; Minor; Kates; Albericio; Barany
Journal of Organic Chemistry, 1996 , vol. 61, # 18 p. 6326 - 6339
反应条件
1: With sulfuric acid; sodium nitrite in acetic acid
T=0°C; Diazotization; 0.333333 h;
2: With sulfuric acid; water; urea
Hydrolysis; 0.166667 h; Heating; Further stages.;
参考文献
Szajnman, Sergio H.; Yan, Wen; Bailey, Brian N.; Docampo, Roberto; Elhalem, Eleonora; Rodriguez, Juan B.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 9 p. 1826 - 1840
反应条件
tert.-butylhydroperoxide; Rhodium trichloride; triphenylphosphine in chlorobenzene
T=160°C; 24 h; Inert atmosphere;
参考文献
Wang, Ping; Rao, Honghua; Hua, Ruimao; Li, Chao-Jun
Organic Letters, 2012 , vol. 14, # 3 p. 902 - 905
反应条件
pyridine hydrochloride in water
参考文献
Tropix, Inc.
Patent: US6162610 A1, 2000 ;
反应条件
1.1: fuming HNO3; H2SO4 / 0.67 h / 0 °C
2.1: 46 percent / H2 / Pd/C / ethyl acetate / 6 h / 20 °C
3.1: aq. NaNO2; H2SO4 / acetic acid / 0.33 h / 0 °C
3.2: 36 percent / urea; H2O; H2SO4 / 0.17 h / Heating
View Scheme
参考文献
Szajnman, Sergio H.; Yan, Wen; Bailey, Brian N.; Docampo, Roberto; Elhalem, Eleonora; Rodriguez, Juan B.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 9 p. 1826 - 1840
