1: 2-Bromo-3-iodothiophene With ethyl magnesium chloride in tetrahydrofuran T=15°C; 0.25 h; 2: p-toluenesulphonyl cyanide in tetrahydrofuran T=20 - 25°C; 1 h; Title compound not separated from byproducts;
参考文献
Christophersen, Claus; Begtrup, Mikael; Ebdrup, Soren; Petersen, Henning; Vedso, Per
Journal of Organic Chemistry, 2003 , vol. 68, # 24 p. 9513 - 9516
caesium carbonate in dimethyl sulfoxide T=150°C; 1.5 h; Inert atmosphere;
参考文献
REGENTS OF THE UNIVERSITY OF MINNESOTA; CHO, Yong-yeon; DONG, Zigang; BODE, Ann, M.; KIM, Dong, Joon; KIM, Myoung, Ok; REDDY, Kanamata, Srinivasa
Patent: WO2013/138341 A1, 2013 ;
Location in patent: Page/Page column 49 ;
