1: 4-chloro-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine With sec.-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: p-toluenesulphonyl cyanide in tetrahydrofuran; hexane
T=20°C; 2 h;
3: With ammonium chloride in tetrahydrofuran; hexane; water
参考文献
ASTELLAS PHARMA INC.
Patent: WO2007/7919 A2, 2007 ;
Location in patent: Page/Page column 46-47 ;
WO 2007/007919 A2
1: (3-bromopyridin-4-yl)-dimethyl-amine With isopropylmagnesium chloride in tetrahydrofuran
T=20°C; 3 h;
2: p-toluenesulphonyl cyanide in tetrahydrofuran
参考文献
Poisson, Thomas; Oudeyer, Sylvain; Levacher, Vincent
Tetrahedron Letters, 2012 , vol. 53, # 26 p. 3284 - 3287