4-(3-溴-4-甲氧基苯基)吡啶合成路线 （共 5 条）
反应条件
bromine; acetic acid T=60°C; 72 h; Inert atmosphere; regioselective reaction;
参考文献
Manley, Paul W.; Acemoglu, Murat; Marterer, Wolfgang; Pachinger, Werner
Organic Process Research and Development, 2003 , vol. 7, # 3 p. 436 - 445
反应条件
1.1: sodium hydroxide / water; toluene / 0.33 h / 0 - 5 °C / pH Ca. 9 2.1: magnesium; iodine / tetrahydrofuran / 3 h / 35 °C / |Inert atmosphere 2.2: 4.25 h / 30 - 45 °C / |Inert atmosphere 3.1: acetic acid; bromine / 72 h / 60 °C / |Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 7, # 3 p. 436 - 445
反应条件
1.1: magnesium; iodine / tetrahydrofuran / 3 h / 35 °C / |Inert atmosphere 1.2: 4.25 h / 30 - 45 °C / |Inert atmosphere 2.1: acetic acid; bromine / 72 h / 60 °C / |Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 7, # 3 p. 436 - 445
反应条件
1.1: magnesium / tetrahydrofuran / |Inert atmosphere 1.2: 10 - 50 °C / |Inert atmosphere; |Cooling 2.1: acetic acid; bromine / 72 h / 60 °C / |Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 7, # 3 p. 436 - 445
反应条件
1.1: magnesium / tetrahydrofuran / |Inert atmosphere 1.2: 10 - 50 °C / |Inert atmosphere; |Cooling 2.1: acetic acid; bromine / 72 h / 60 °C / |Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 7, # 3 p. 436 - 445
