1,3-二氧-2-( 2,6-二氧哌啶-3-基) -5-硝基异二氢吲哚合成路线 （共 8 条）
反应条件
in acetic acid 4.5 h; RefluxInert atmosphere;
参考文献
Greig, Nigel H.; Luo, Weiming; Tweedie, David; Holloway, Harold W.; Yu, Qian-Sheng; Goetzl, Edward J.
Patent: US2013/143922 A1, 2013 ;
Location in patent: Paragraph 0089 ;
反应条件
1: CDI / tetrahydrofuran / Heating 2: H2, aq. HCl / 10 percent Pd/C / ethyl acetate / 2585.74 - 3102.89 Torr 3: AcOH / Heating View Scheme
参考文献
Muller, George W.; Chen, Roger; Huang, Shaei-Yun; Corral, Laura G.; Wong, Lu Min; Patterson, Rebecca T.; Chen, Yuxi; Kaplan, Gilla; Stirling, David I.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 11 p. 1625 - 1630
反应条件
1: H2, aq. HCl / 10 percent Pd/C / ethyl acetate / 2585.74 - 3102.89 Torr 2: AcOH / Heating View Scheme
参考文献
Muller, George W.; Chen, Roger; Huang, Shaei-Yun; Corral, Laura G.; Wong, Lu Min; Patterson, Rebecca T.; Chen, Yuxi; Kaplan, Gilla; Stirling, David I.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 11 p. 1625 - 1630
反应条件
acetic acid Heating;
参考文献
Muller, George W.; Chen, Roger; Huang, Shaei-Yun; Corral, Laura G.; Wong, Lu Min; Patterson, Rebecca T.; Chen, Yuxi; Kaplan, Gilla; Stirling, David I.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 11 p. 1625 - 1630
反应条件
acetic acid RefluxMolecular sieve;
参考文献
Contino-Pepin, Christiane; Parat, Audrey; Perino, Sandrine; Lenoir, Christine; Vidal, Michel; Galons, Herve; Karlik, Stephen; Pucci, Bernard
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 878 - 881
反应条件
1: With hydrogenchloride; iron in ethanol; water T=65 - 70°C; 2 h; 2: With ammonia in water pH=7 - 8;
参考文献
GENERICS [UK] LIMITED
Patent: US2011/263649 A1, 2011 ;
Location in patent: Page/Page column 6 ;
反应条件
hydrogen; palladium on activated charcoal in acetone P=2585.74 - 3102.89 Torr;
参考文献
Celgene Corporation
Patent: US6335/349 B1, 2002 ;
Location in patent: Example 1 ;
Title/Abstract Full Text Show Details
Celgene Corporation
Patent: US6335349 B1, 2002 ;
Location in patent: Example 1 ;
反应条件
palladium on activated charcoal; hydrogen T=20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 3 p. 878 - 881
