sodium hydroxide in N,N-dimethyl-formamide 4 h; Ambient temperature;

1: 77 percent / 1N aq. NaOH / dimethylformamide / 4 h / Ambient temperature 2: 1.) 47percent aq. HBr, 2.) Ph3PBr2 / 1.) EtOH, reflux, 15 min, 2.) DMF, RT, 4 h View Scheme