1: N-(2-Methoxycarbonyl-1-cycloheptenyl)-L-tert-leucine dimethylamide With copper diacetate in acetone T=23°C; 1 h; 2: methyl vinyl ketone in acetone T=23°C; Michael reaction; 3: With hydrogenchloride T=0°C; Further stages.;

1: N-(2-Methoxycarbonyl-1-cycloheptenyl)-L-tert-leucine diethylamide With copper diacetate in acetone T=23°C; 1 h; 2: methyl vinyl ketone in acetone T=23°C; Michael reaction; 3: With hydrogenchloride T=0°C; Further stages.;

iron(III) chloride 1 h; Ambient temperature;

1.1: 22 percent / aq. HCl; molecular sieves 4 Angstroem / toluene / 60 - 65 °C 2.1: Cu(OAc)2*H2O / acetone / 1 h / 23 °C 2.2: acetone / 23 °C 2.3: 75 percent / aq. HCl / 0 °C View Scheme

methanol; benzene