(9ci)-4-甲基-1H-苯并咪唑-2-甲醇合成路线 (共 5 条)
反应条件
hydrogenchloride 2 h; Heating;
参考文献
Roth, Thomas; Morningstar, Marshall L.; Boyer, Paul L.; Hughes, Stephen H.; Buckheit Jr., Robert W.; Michejda, Christopher J.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 26 p. 4199 - 4207
反应条件
hydrogenchloride in water 2 h; Heating / reflux;
参考文献
The United States of America as represented by the Department of Health and Human Services
Patent: US6369235 B1, 2002 ;
Location in patent: Example 2 ;
参考文献
Journal of the Chemical Society, , p. 1600,1602
反应条件
potassium permanganate; sodium carbonate in water T=100°C; 2 h;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2004/22060 A2, 2004 ;
Location in patent: Page/Page column 33-34 ;
WO 2004/022060 A2
反应条件
1: 84 percent / pyridine / 4 h / Ambient temperature
2: 93 percent / NaH / tetrahydrofuran / 4 h
3: 98 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature
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参考文献
Roth, Thomas; Morningstar, Marshall L.; Boyer, Paul L.; Hughes, Stephen H.; Buckheit Jr., Robert W.; Michejda, Christopher J.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 26 p. 4199 - 4207