3,4-二氢-4-氧-8-喹唑啉羧酸合成路线 （共 5 条）
反应条件
1: With ammonium hydroxide; ammonium acetate T=80°C; 2 h; 2: With methanol T=80°C; 72 h; pressure bottle;
参考文献
MERCK PATENT GMBH; HUCK, Bayard, R.; JONES, Reinaldo; XIAO, Yufang; NEAGU, Constantin; BANKSTON, Donald; GOUTOPOULOS, Andreas
Patent: WO2012/69146 A1, 2012 ;
Location in patent: Page/Page column 25 ;
参考文献
Journal of the American Chemical Society, , vol. 70, p. 4061
反应条件
1.1: 4 h / 140 °C 2.1: ammonium hydroxide; ammonium acetate / 2 h / 80 °C 2.2: 72 h / 80 °C / pressure bottle View Scheme
反应条件
1: With sulfuric acid 48 h; Reflux; 2: With sodium hydroxide T=20°C; pH=~ 8;
参考文献
MERCK PATENT GMBH; SUTTON, Amanda E.; RICHARDSON, Thomas E.; HUCK, Bayard R.; KARRA, Srinivasa R.; CHEN, Xiaoling; XIAO, Yufang; GOUTOPOULOS, Andreas; LAN, Ruoxi; PERREY, David; VANDEVEER, Harold, George; LIU-BUJALSKI, Lesley; STIEBER, Frank; HODOUS, Brian L.; QIU, Hui; JONES, Reinaldo C.; HEASLEY, Brian
Patent: WO2010/93419 A1, 2010 ;
Location in patent: Page/Page column 173; 194 ;
WO 2010/093419 A1
反应条件
1: sulfuric acid / Inert atmosphere; Reflux
2: N-ethyl-N,N-diisopropylamine; trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / acetonitrile / 90 °C
View Scheme
参考文献
MERCK PATENT GMBH; HUCK, Bayard, R.; JONES, Reinaldo; XIAO, Yufang; NEAGU, Constantin; BANKSTON, Donald; GOUTOPOULOS, Andreas
Patent: WO2012/69146 A1, 2012 ;
