2-(2-羟乙基)苯硼酸半酯合成路线 （共 6 条）
反应条件
1: With n-butyllithium in tetrahydrofuran T=-78 - 20°C; Inert atmosphere; 2: With hydrogenchloride in tetrahydrofuran; water T=20°C; 1 h;
参考文献
ANACOR PHARMACEUTICALS, INC.; JACOBS, Robert, T.; CHEN, Daitao; ORR, Matthew; PLATTNER, Jacob, J.
Patent: WO2011/116348 A1, 2011 ;
Location in patent: Page/Page column 78 ;
反应条件
1: With n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran T=-78 - 20°C; Inert atmosphere; 2: With hydrogenchloride in tetrahydrofuran; water T=20°C; 1 h; Inert atmosphere;
参考文献
Tomsho, John W.; Pal, Arnab; Hall, Dennis G.; Benkovic, Stephen J.
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 1 p. 48 - 52
反应条件
1.1: camphor-10-sulfonic acid / dichloromethane / 2 h / 20 °C 2.1: n-butyllithium / tetrahydrofuran / -78 - 20 °C / Inert atmosphere 2.2: 1 h / 20 °C View Scheme
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Heating;
参考文献
Journal of Organic Chemistry, , vol. 34, # 6 p. 1660 - 1663
反应条件
1: aq. HCl 2: LiAlH4 / tetrahydrofuran / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 34, # 6 p. 1660 - 1663
反应条件
1: aq. KOH 2: aq. HCl 3: LiAlH4 / tetrahydrofuran / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 34, # 6 p. 1660 - 1663
