1,2-二氯-3-(氯甲基)-4-硝基-苯合成路线 (共 3 条)
参考文献
Roberts Laboratories Inc.
Patent: US6194420 B1, 2001 ;
反应条件
1: With triethylamine in acetonitrile
T=20 - 75°C; 2.5 - 2.83333 h;
2: With hydrogenchloride in ethanol; isopropyl alcohol
T=5 - 20°C;
参考文献
CHEMISCH-PHARMAZEU TISCHES LABOR ROLF SACHSE GMBH
Patent: WO2004/63172 A1, 2004 ;
Location in patent: Page/Page column 9-10 ;
反应条件
triethylamine in ethanol
20 h; Heating;
参考文献
Kienzle; Kaiser; Chodnekar
European Journal of Medicinal Chemistry, 1982 , vol. 17, # 6 p. 547 - 556