4-甲氧基-2-(苯基氨基)苯甲酸合成路线 （共 11 条）
反应条件
sodium hydroxide; water in tetrahydrofuran; methanol T=60°C; 4 h; Product distribution / selectivity;
参考文献
MERCK and CO., INC.
Patent: WO2005/30217 A1, 2005 ;
Location in patent: Page/Page column 28 ;
WO 2005/030217 A1
参考文献
Shinkai, Seiji; Hamada, Hisatake; Kuroda, Hideo; Manabe, Osamu
Journal of Organic Chemistry, 1981 , vol. 46, # 11 p. 2333 - 2338
反应条件
1.1: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl / toluene / 20 - 120 °C / Inert atmosphere 2.1: potassium hydroxide / ethanol; water / 20 - 100 °C / Inert atmosphere 2.2: 0 °C / pH 2 / Inert atmosphere View Scheme
参考文献
Adeniji, Adegoke O.; Twenter, Barry M.; Byrns, Michael C.; Jin, Yi; Chen, Mo; Winkler, Jeffrey D.; Penning, Trevor M.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2311 - 2323
反应条件
1: Raney nickel; methanol / Hydrogenation 2: K2CO3; CuCl; copper-powder / weiteres Reagens: Isopentylalkohol View Scheme
参考文献
Brockmann et al.
Chemische Berichte, 1956 , vol. 89, p. 2174,2178
反应条件
1: NaOH-solution 2: potassium permanganate; water 3: amyl alcohol; potash; copper powder View Scheme
参考文献
Ullmann; Wagner
Justus Liebigs Annalen der Chemie, 1907 , vol. 355, p. 366
Justus Liebigs Annalen der Chemie, 1909 , vol. 371, p. 388
反应条件
1: potassium permanganate; water 2: amyl alcohol; potash; copper powder View Scheme
参考文献
Ullmann; Wagner
Justus Liebigs Annalen der Chemie, 1907 , vol. 355, p. 366
Justus Liebigs Annalen der Chemie, 1909 , vol. 371, p. 388
反应条件
1: Reaktion ueber mehrere Stufen 2: NaOH-solution 3: potassium permanganate; water 4: amyl alcohol; potash; copper powder View Scheme
参考文献
Ullmann; Wagner
Justus Liebigs Annalen der Chemie, 1907 , vol. 355, p. 366
Justus Liebigs Annalen der Chemie, 1909 , vol. 371, p. 388
反应条件
copper; potassium carbonate; copper(l) chloride weiteres Reagens: Isopentylalkohol;
参考文献
Brockmann et al.
Chemische Berichte, 1956 , vol. 89, p. 2174,2178
反应条件
3-methyl-1-butanol; copper
参考文献
Scherlin et al.
Zhurnal Obshchei Khimii, 1938 , vol. 8, p. 884,887
Chem. Zentralbl., 1939 , vol. 110, # I p. 4324
反应条件
1: 65 percent / concd. H2SO4 / 100 °C
2: C2H5OH, Na
3: K2Cr2O7
View Scheme
参考文献
Scherlin et al.
Zhurnal Obshchei Khimii, 1938 , vol. 8, p. 884,887
Chem. Zentralbl., 1939 , vol. 110, # I p. 4324
