1-(6-氨基-9H-嘌呤-9-基)-1-脱氧-2,3-O-(1-甲基乙亚基)-beta-D-呋喃核糖酸合成路线 （共 10 条）
反应条件
ruthenium trichloride; sodium periodate in tetrachloromethane; water; acetonitrile Ambient temperature;
参考文献
Singh, Ambarish K.; Varma, Rajender S.
Tetrahedron Letters, 1992 , vol. 33, # 17 p. 2307 - 2310
反应条件
1: p-toluenesulfonic acid / acetone / 1 h / Ambient temperature 2: 86 percent / KMnO4, KOH / H2O / 24 h / Ambient temperature View Scheme
参考文献
Ha; Nair
Tetrahedron Letters, 1996 , vol. 37, # 10 p. 1567 - 1570
反应条件
triethylamine in chloroform; water T=25°C; hydrolysis, rate accelerations in the presence of several additives, addition of a carbazole derivative;
参考文献
Pieters, Roland J.; Huc, Ivan; Rebek, Julius
Chemistry--A European Journal, 1995 , vol. 1, # 3 p. 183 - 192
反应条件
1: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / dimethylformamide / 3 h / 20 °C 2: dimethylformamide / 1 h / 20 °C 3: 80percent aq. TFA / 20 °C View Scheme
参考文献
Olsson; Kusachi; Thompson; Ukena; Padgett; Daly
Journal of medicinal chemistry, 1986 , vol. 29, # 9 p. 1683 - 1689
反应条件
1: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / dimethylformamide / 3 h / 20 °C 2: dimethylformamide / 1 h / 20 °C 3: 80percent aq. TFA / 20 °C View Scheme
参考文献
Umino; Yoshioka; Saitoh; Minakawa; Nakata; Matsuda
Journal of Medicinal Chemistry, 2001 , vol. 44, # 2 p. 208 - 214
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 3 h;
参考文献
Debnath, Joy; Dasgupta, Swagata; Pathak, Tanmaya
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 23 p. 8257 - 8263
反应条件
1: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / dimethylformamide / 3 h / 20 °C 2: NH3 / dimethylformamide / 1 h / 20 °C 3: 80percent aq. TFA / 20 °C View Scheme
参考文献
Umino; Yoshioka; Saitoh; Minakawa; Nakata; Matsuda
Journal of Medicinal Chemistry, 2001 , vol. 44, # 2 p. 208 - 214
反应条件
1: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / dimethylformamide / 3 h / 20 °C 2: H2NOH / dimethylformamide / 1 h / 20 °C 3: 80percent aq. TFA / 20 °C View Scheme
参考文献
Umino; Yoshioka; Saitoh; Minakawa; Nakata; Matsuda
Journal of Medicinal Chemistry, 2001 , vol. 44, # 2 p. 208 - 214
反应条件
1: 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl / dimethylformamide / 3 h / 20 °C 2: dimethylformamide / 1 h / 20 °C 3: 80percent aq. TFA / 20 °C View Scheme
参考文献
De Zwart, Maarten; Kourounakis, Angeliki; Kooijman, Huub; Spek, Anthony L.; Link, Regina; Von Frijtag Drabbe Kuenzel, Jacobien K.; IJzerman, Ad P.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 8 p. 1384 - 1392
反应条件
(i) MeLi, THF, (ii) aq. NH4Cl; Multistep reaction;
参考文献
Harper; Hampton
The Journal of organic chemistry, 1972 , vol. 37, # 5 p. 795 - 797
