ammonium chloride in formamide T=120°C; 20 h;

in chloroform; water

1: 94 percent / CaCO3 / H2O; CH2Cl2 / 1) 0-5 deg C, 1 h; 2) 20 deg C, 20 h; 2: 90 percent / ethyl acetate / 20 h / 0 °C 3: 95 percent / ethyl acetate / 20 h / 60 °C 4: 86 percent / ammonium chloride / formamide / 20 h / 120 °C View Scheme

1: 90 percent / ethyl acetate / 20 h / 0 °C 2: 95 percent / ethyl acetate / 20 h / 60 °C 3: 86 percent / ammonium chloride / formamide / 20 h / 120 °C View Scheme

1: 95 percent / ethyl acetate / 20 h / 60 °C 2: 86 percent / ammonium chloride / formamide / 20 h / 120 °C View Scheme

hydrogen; palladium on activated charcoal in ethanol; water T=20°C;