4-溴-2,6-二氯苯甲醚合成路线 （共 7 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C; 16 h;
参考文献
Anacor Pharmaceuticals, Inc.; Eli Lilly and Company; Akama, Tsutomu; Balko, Terry William; Defauw, Jean Marie; Plattner, Jacob J.; White, William Hunter; Winkle, Joseph Raymond; Zhang, Yong-Kang; Zhou, Yasheen
Patent: US2013/131016 A1, 2013 ;
Location in patent: Paragraph 0296; 0297 ;
参考文献
Li, James J.; Norton, Monica B.; Reinhard, Emily J.; Anderson, Gary D.; Gregory, Susan A.; Isakson, Peter C.; Koboldt, Carol M.; Masferrer, Jaime L.; Perkins, William E.; Seibert, Karen; Zhang, Yan; Zweifel, Ben S.; Reitz, David B.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1846 - 1856
反应条件
1.1: 33 percent / Br / acetic acid 2.1: aque. NaOH 2.2: 52 percent / 0.5 h / Heating View Scheme
参考文献
Anacor Pharmaceuticals, Inc.; Eli Lilly and Company; Akama, Tsutomu; Balko, Terry William; Defauw, Jean Marie; Plattner, Jacob J.; White, William Hunter; Winkle, Joseph Raymond; Zhang, Yong-Kang; Zhou, Yasheen
Patent: US2013/131016 A1, 2013 ;
反应条件
Oxonereg;; ammonium chloride in acetonitrile T=20°C; 24 h;
参考文献
Narender; Mohan, K.V.V. Krishna; Srinivasu; Kulkarni; Raghavan
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 6 p. 1335 - 1338
反应条件
1: With sodium hydroxide 2: 0.5 h; Heating;
参考文献
Lehmler, Hans-Joachim; Robertson, Larry W.
Chemosphere, 2001 , vol. 45, # 8 p. 1119 - 1127
反应条件
chlorine T=30°C; 3 h; Yield given;
参考文献
Watson, William David
Journal of Organic Chemistry, 1982 , vol. 47, # 27 p. 5270 - 5276
反应条件
1: 5-bromo-1,3-dichloro-2-methoxybenzene With n-butyllithium in tetrahydrofuran; hexane T=-75°C; 0.25 h; 2: carbon dioxide in tetrahydrofuran; hexane T=25°C;
参考文献
Schlosser, Manfred; Heiss, Christophe; Marzi, Elena; Scopelliti, Rosario
European Journal of Organic Chemistry, 2006 , # 19 p. 4398 - 4404
