3,4-二甲基苯基异硫氰酸酯合成路线 (共 6 条)
反应条件
acrylic acid methyl ester in water T=20°C; 1.5 h;
参考文献
Organic and Biomolecular Chemistry, , vol. 8, # 7 p. 1674 - 1678
反应条件
sodium hydrogencarbonate in dichloromethane; water T=0 - 20°C;
参考文献
Journal of Heterocyclic Chemistry, , vol. 47, # 3 p. 734 - 739
反应条件
1: acetone / 20 °C 2: bis(trichloromethyl) carbonate / chloroform / 10 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 20 p. 7911 - 7924
反应条件
in ethanol 4 h; Heating;
参考文献
Journal of Pharmaceutical Sciences, , vol. 78, # 12 p. 999 - 1002
反应条件
1: With hydrazinecarboxylic acid tert-butyl ester
2: With hydrogenchloride in water
参考文献
Hall, Matthew D.; Brimacombe, Kyle R.; Varonka, Matthew S.; Pluchino, Kristen M.; Monda, Julie K.; Li, Jiayang; Walsh, Martin J.; Boxer, Matthew B.; Warren, Timothy H.; Fales, Henry M.; Gottesman, Michael M.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 16 p. 5878 - 5889
反应条件
in ethyl acetate
0.333333 - 0.5 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/122241 A1, 2007 ;
Location in patent: Page/Page column 68-69 ;