3-氯-4-甲基异硫氰酸苯酯合成路线 （共 9 条）
反应条件
triethylamine in benzene T=10 - 20°C;
参考文献
Zakrzewski, Jerzy; Krawczyk, Maria
Phosphorus, Sulfur and Silicon and the Related Elements, 2009 , vol. 184, # 7 p. 1880 - 1903
反应条件
trichlorosilane; triethylamine in benzene T=20°C; Elimination; 1 h;
参考文献
Zhang, Xuechun; Lee, Young K.; Kelley, James A.; Burke Jr., Terrence R.
Journal of Organic Chemistry, 2000 , vol. 65, # 19 p. 6237 - 6240
反应条件
1: 98 percent / tetrahydrofuran / 0.5 h / 20 °C 2: 51 percent / Et3N; HSiCl3 / benzene / 1 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 19 p. 6237 - 6240
反应条件
1: With 1,4-diaza-bicyclo[2.2.2]octane T=20°C; 12 h; 2: With bis(trichloromethyl) carbonate 2 h; Reflux;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 17, # 8 p. 3177 - 3188
反应条件
acetic anhydride 0.333333 h; Heating;
参考文献
Pharmazie, , vol. 37, # 2 p. 147 - 147
反应条件
hydrazine hydrate in ethanol
参考文献
Kamel
Pharmazie, 1982 , vol. 37, # 2 p. 147 - 147
反应条件
in benzene T=0 - 20°C;
参考文献
Zakrzewski, Jerzy; Krawczyk, Maria
Phosphorus, Sulfur and Silicon and the Related Elements, 2009 , vol. 184, # 7 p. 1880 - 1903
反应条件
ammonia in methanol; acetonitrile T=20°C; 2 h;
参考文献
CELGENE CORPORATION; MULLER, George, W.; RUCHELMAN, Alexander, L.
Patent: WO2010/53732 A1, 2010 ;
Location in patent: Page/Page column 75-76 ;
反应条件
1: 2-chloro-4-isothiocyanato-1-methylbenzene; sodium hydrogen cyanamide in methanol
T=20°C; P=760.051 Torr; 1 h; Inert atmosphere;
2: methyl iodide in methanol
T=20°C; P=760.051 Torr; 4 h; Inert atmosphere;
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BILOTTA, Joseph Anthony; CHEN, Zhi; CHIN, Elbert; DING, Qingjie; ERICKSON, Shawn David; GABRIEL, Stephen Deems; KLUMPP, Klaus; MA, Han; MERTZ, Eric; PLANCHER, Jean-Marc; WEIKERT, Robert James
Patent: WO2014/6066 A1, 2014 ;
Location in patent: Paragraph 0365 ;
