三乙二醇二(对甲苯磺酸酯)合成路线 （共 90 条）
反应条件
sodium t-butanolate in 1,4-dioxane; tert-butyl alcohol
2 h;
参考文献
Maeda; Furuyoshi; Nakatsuji; Okahara
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 10 p. 3073 - 3077
反应条件
sodium methylate
1.) sodium methoxide, dioxane, diol, 10 min 2.) 1,2-bis<2'-(toluene-p-sulphonyloxy)ethoxy>ethane, dioxane, 5 min, reflux; Multistep reaction;
参考文献
Bowsher, Brian R.; Rest, Antony J.; Main, Brian G.
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1984 , p. 1421 - 1426
反应条件
lithium bromide; lithium tert-butylate
1.) xylene, t-BuOH, 2.) xylene, t-BuOH, 85-95 deg C, 2 d; Yield given. Multistep reaction;
参考文献
Miyazaki, Takeshi; Yanagida, Shozo; Itoh, Akira; Okahara, Mitsuo
Bulletin of the Chemical Society of Japan, 1982 , vol. 55, # 7 p. 2005 - 2009
反应条件
potassium hydroxide in 1,4-dioxane
T=80°C; 18 h;
参考文献
Belohradsky, Martin; Stibor, Ivan; Holy, Petr; Zavada, Jiri
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 10 p. 2500 - 2507
反应条件
potassium tert-butylate in tetrahydrofuran
72 h; Heating;
参考文献
Hu, Hui; Bartsch, Richard A.
Journal of Heterocyclic Chemistry, 2004 , vol. 41, # 4 p. 557 - 562
反应条件
1.1: sodium azide; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 16 h / 80 °C
2.1: hydrogenchloride; triphenylphosphine / water; toluene / 16 h / 0 - 20 °C
3.1: triethylamine / dichloromethane / 0.83 h
4.1: triphenylphosphine / tetrahydrofuran / 5 h
4.2: 2 h
5.1: sodium hydrogencarbonate / water / 1.25 h / 0 - 20 °C / Saturated solution
6.1: dichloromethane / 0.17 h
View Scheme
参考文献
Willems, Lianne I.; Verdoes, Martijn; Florea, Bogdan I.; Van Der Marel, Gijsbert A.; Overkleeft, Herman S.
ChemBioChem, 2010 , vol. 11, # 12 p. 1769 - 1781
反应条件
1: 4-lt;N,N-bis(2-hydroxyethyl)aminogt;benzaldehyde With sodium hydride in tetrahydrofuran; mineral oil
0.5 h; RefluxInert atmosphere;
2: triethylene glycol di-p-tosylate in tetrahydrofuran; mineral oil
T=70°C; 48 h; Inert atmosphere;
参考文献
Wu, Chia-Shing; Chen, Chiao-Pei; Chen, Yun
Journal of Polymer Science, Part A: Polymer Chemistry, 2013 , vol. 51, # 18 p. 3975 - 3984
反应条件
1: sodium hydride / tetrahydrofuran
2: trichlorophosphate / N,N-dimethyl-formamide
View Scheme
参考文献
Zheng, Zheng; Yu, Zhipeng; Yang, Mingdi; Jin, Feng; Zhang, Qiong; Zhou, Hongping; Wu, Jieying; Tian, Yupeng
Journal of Organic Chemistry, 2013 , vol. 78, # 7 p. 3222 - 3234
反应条件
1: NaH / tetrahydrofuran
2: SnCl2*2H2O / ethyl acetate / 40 °C
View Scheme
参考文献
Zeng, Wei; Du, Ying; Li, Hongbo; Lu, Xiaoxia; Qin, Shengying
Organic Preparations and Procedures International, 2003 , vol. 35, # 2 p. 228 - 231
反应条件
sodium methylate
1.) sodium methoxide, dioxane, diol, 10 min 2.) 1,2-bis<2'-(toluene-p-sulphonyloxy)ethoxy>ethane, dioxane, 5 min, reflux; Multistep reaction;
参考文献
Bowsher, Brian R.; Rest, Antony J.; Main, Brian G.
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1984 , p. 1421 - 1426
