三乙二醇二(对甲苯磺酸酯)合成路线 （共 90 条）
反应条件
sodium methylate
1.) sodium methoxide, dioxane, diol, 10 min 2.) 1,2-bis<2'-(toluene-p-sulphonyloxy)ethoxy>ethane, dioxane, 5 min, reflux; Yield given. Multistep reaction;
参考文献
Bowsher, Brian R.; Rest, Antony J.; Main, Brian G.
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1984 , p. 1421 - 1426
反应条件
1: 59 percent / t-BuONa / 2-methyl-propan-2-ol; dioxane / 2 h / 40 °C
2: 41 percent / 6 h / 170 °C
View Scheme
参考文献
Maeda, Hirokazu; Furuyoshi, Shigeo; Nakatsuji, Yohji; Okahara, Mitsuo
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 1 p. 212 - 218
反应条件
sodium t-butanolate in 1,4-dioxane; tert-butyl alcohol
T=40°C; 2.5 h;
参考文献
Maeda, Hirokazu; Kikui, Takashi; Nakatsuji, Yohji; Okahara, Mitsuo
Journal of Organic Chemistry, 1982 , vol. 47, # 26 p. 5167 - 5171
反应条件
potassium hydroxide in 1,4-dioxane
T=60°C; 2 h;
参考文献
Ikeda, Isao; Emura, Hiroshi; Yamamura, Shingo; Okahara, Mitsuo
Journal of Organic Chemistry, 1982 , vol. 47, # 26 p. 5150 - 5153
反应条件
sodium hydride
1) 30 min, r. t., THF, 2) 6 h, reflux, THF; Yield given. Multistep reaction;
参考文献
Weber, Edwin
Liebigs Annalen der Chemie, 1983 , # 5 p. 770 - 801
反应条件
1: 46 percent / NaH / tetrahydrofuran
2: 98 percent / H2, trace HCl / Pd-C
3: 96 percent / Na2CO3 / acetonitrile / 24 h / Heating
View Scheme
参考文献
Delgado, Milagros; Echegoyen, Luis; Gatto, Vincent J.; Gustowski, Deborah A.; Gokel, George W.
Journal of the American Chemical Society, 1986 , vol. 108, # 14 p. 4135 - 4138
反应条件
1: 46 percent / NaH / tetrahydrofuran
2: 98 percent / H2, trace HCl / Pd-C
3: 85 percent / Na2CO3 / acetonitrile / 24 h / Heating
View Scheme
参考文献
Delgado, Milagros; Echegoyen, Luis; Gatto, Vincent J.; Gustowski, Deborah A.; Gokel, George W.
Journal of the American Chemical Society, 1986 , vol. 108, # 14 p. 4135 - 4138
反应条件
sodium hydride in tetrahydrofuran
参考文献
Schultz, Rose Ann; Dishong, Dennis M.; Gokel, George W.
Tetrahedron Letters, 1981 , vol. 22, # 28 p. 2623 - 2626
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Schultz, Rose Ann; Schlegel, Eric; Dishong, Dennis M.; Gokel, George W.
Journal of the Chemical Society, Chemical Communications, 1982 , # 4 p. 242 - 243
反应条件
potassium hydroxide in 1,4-dioxane
T=80°C; 18 h;
参考文献
Belohradsky, Martin; Stibor, Ivan; Holy, Petr; Zavada, Jiri
Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 10 p. 2500 - 2507
参考文献
Sonveaux, E.
Bulletin des Societes Chimiques Belges, 1982 , vol. 91, # 1 p. 91 - 92
