三乙二醇二(对甲苯磺酸酯)合成路线 （共 90 条）
反应条件
1: 80 percent
2: 75 percent / pyridine / benzene
3: 80 percent / B2H6 / tetrahydrofuran / 2 h
View Scheme
参考文献
Sonveaux, E.
Tetrahedron, 1984 , vol. 40, # 4 p. 793 - 798
反应条件
sodium methylate
1.) sodium methoxide, dioxane, diol, 10 min 2.) 1,2-bis<2'-(toluene-p-sulphonyloxy)ethoxy>ethane, dioxane, 5 min, reflux; Yield given. Multistep reaction;
参考文献
Bowsher, Brian R.; Rest, Antony J.; Main, Brian G.
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1984 , p. 1421 - 1426
反应条件
potassium tert-butylate in tetrahydrofuran
T=35°C; 72 h;
参考文献
Rastetter, William H.; Phillion, Dennis P.
Journal of Organic Chemistry, 1981 , vol. 46, # 16 p. 3209 - 3214
反应条件
lithium hydroxide; sodium hydroxide
1.) THF, 1 h, reflux, 2.) 96 h, 66 deg C; Yield given. Multistep reaction;
参考文献
Liu, Yu; Inoue, Yoshihisa; Hakushi, Tadao
Bulletin of the Chemical Society of Japan, 1990 , vol. 63, # 10 p. 3044 - 3046
反应条件
sodium azide in N,N-dimethyl-formamide
参考文献
Gavrilyuk, Julia I.; Wuellner, Ulrich; Barbas III, Carlos F.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 5 p. 1421 - 1424
反应条件
sodium hydroxide in tetrahydrofuran
参考文献
Bowsher, Brian R.; Rest, Antony J.; Main, Brian G.
Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1972-1999), 1984 , p. 1421 - 1426
反应条件
potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in benzene
7 h; Ambient temperature;
参考文献
Singh, Paramjit; Kumar, Manoj; Singh, Harjit
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 861 - 862
反应条件
tetrabutyl-ammonium chloride; potassium carbonate in N,N-dimethyl-formamide
T=80°C; 12 h;
参考文献
Ostaszewski, Ryszard; Jacobsson, Ulla; Jurczak, Janusz
Bulletin of the Polish Academy of Sciences, Chemistry, 1988 , vol. 36, # 5-6 p. 221 - 228
反应条件
tetrabutyl-ammonium chloride; potassium carbonate in N,N-dimethyl-formamide
T=80°C; 12 h;
参考文献
Ostaszewski, Ryszard; Jacobsson, Ulla; Jurczak, Janusz
Bulletin of the Polish Academy of Sciences, Chemistry, 1988 , vol. 36, # 5-6 p. 221 - 228
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in benzene
8 h; Heatingother bases, under liquid-liquid PT-conditions, reaction with further p-toluenesulphonate ester of diols;
参考文献
Singh, Paramjit; Jain, Anupa
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1988 , vol. 27, # 1-12 p. 790 - 792
