11a-羟基坎利酮丙烯酸甲酯合成路线 （共 15 条）
反应条件
in methanol T=62 - 115°C; Product distribution / selectivity;
参考文献
PHARMACIA CORPORATION
Patent: WO2006/32970 A2, 2006 ;
Location in patent: Page/Page column 68-69 ;
反应条件
in methanol; hexane; toluene T=20°C;
参考文献
US2004/97475 A1, ;
Page/Page column 4-6; 11-12 ;
反应条件
potassium carbonate T=0 - 20°C;
参考文献
Zhang, Bin; Chen, Hongli; Tang, Huanyu; Feng, Huijin; Li, Yuanchao
Steroids, 2012 , vol. 77, # 11 p. 1086 - 1091
反应条件
1: 20 h; Heating / reflux; 2: With hydrogenchloride in methanol; water
参考文献
G.D. SEARLE and CO.
Patent: EP1223174 A2, 2002 ;
Location in patent: Example 22 ;
反应条件
in methanol 23.5 h; Heating / reflux;
参考文献
G.D. SEARLE and CO.
Patent: EP1223174 A2, 2002 ;
Location in patent: Example 32A-1 ;
反应条件
Beuveria bassiana ATCC 7159 in water
参考文献
EP1223174 A2, ;
Example 19C ;
反应条件
1.1: potassium carbonate; dimethyloctadecylbenzylammonium chloride / N,N-dimethyl-formamide / 48 h / 90 °C 2.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C 2.2: 4 h 3.1: potassium carbonate / 0 - 20 °C View Scheme
参考文献
Steroids, , vol. 77, # 11 p. 1086 - 1091
反应条件
1.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C 1.2: 4 h 2.1: potassium carbonate / 0 - 20 °C View Scheme
参考文献
Steroids, , vol. 77, # 11 p. 1086 - 1091
反应条件
1.1: potassium carbonate; dimethyloctadecylbenzylammonium chloride; nitromethane / N,N-dimethyl-formamide / 48 h / 90 °C 2.1: acetic acid / N,N-dimethyl-formamide / 0.5 h / 45 °C 2.2: 4 h 3.1: potassium carbonate / 0 - 20 °C View Scheme
参考文献
Steroids, , vol. 77, # 11 p. 1086 - 1091
参考文献
G.D. SEARLE and CO.
Patent: EP1223174 A2, 2002 ;
Location in patent: Example 33 ;
