11a-羟基坎利酮丙烯酸甲酯合成路线 （共 15 条）
反应条件
Mycobacterium fortuitum
参考文献
Synlett, , # 3 p. 418 - 422
反应条件
Flavobacterium dehydrogenans
参考文献
Synlett, , # 3 p. 418 - 422
反应条件
1: With methanesulfonyl chloride; triethylamine in dichloromethane T=5°C; 1 h; 2: With formic acid; potassium formiate; acetic anhydride T=70 - 95°C; 5 - 9 h;
参考文献
G.D. SEARLE and CO.
Patent: EP1223174 A2, 2002 ;
Location in patent: Example 36A ;
反应条件
1: With methanesulfonyl chloride; triethylamine in dichloromethane T=0°C; 1.41667 h; 2: With formic acid; potassium formiate; acetic anhydride T=40 - 95°C; 2 h;
参考文献
EP1223174 A2, ;
Example 37A, 37D, 47B ;
反应条件
1: triethylamine / dichloromethane / 0 °C 2: potassium formiate; formic acid / acetic anhydride / 100 °C 3: .alpha.,.alpha.,.alpha.-trichloroacetamide; dihydrogen peroxide; dipotassium hydrogenphosphate / dichloromethane / 10 - 20 °C View Scheme
参考文献
Zhang, Bin; Chen, Hongli; Tang, Huanyu; Feng, Huijin; Li, Yuanchao
Steroids, 2012 , vol. 77, # 11 p. 1086 - 1091
