N-[(1S,2S,4S)-4-氨基-2-羟基-5-苯基-1-(苯基甲基)戊基]-2-(2,6-二甲基苯氧基)乙酰胺合成路线 （共 10 条）
参考文献
Abbott Laboratories
Patent: EP1170289 A2, 2002 ;
Location in patent: Page 42 ;
反应条件
hydrogenchloride; sodium hydrogencarbonate in diethyl ether; water
参考文献
US5914332 A1, ;
US 5914332 A
反应条件
1: EDAC; HOBt 2: H2 / Pd(OH)2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 11 p. 1351 - 1353
反应条件
1: EDC 2: trifluoroacetic acid View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 21 p. 3101 - 3103
反应条件
1: Pd(OH)2; HCO2NH4 2: EDC 3: trifluoroacetic acid View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 21 p. 3101 - 3103
反应条件
1: Pd(OH)2; HCO2NH4 2: EDC 3: trifluoroacetic acid View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 21 p. 3101 - 3103
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride
参考文献
Sham, Hing L; Betebenner, David A; Herrin, Thomas; Kumar, Gondi; Saldivar, Ayda; Vasavanonda, Sudthida; Molla, Akhter; Kempf, Dale J; Plattner, Jacob J; Norbeck, Daniel W
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 11 p. 1351 - 1353
反应条件
N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide in N,N-dimethyl-formamide
参考文献
Abbott Laboratories
Patent: EP1170289 A2, 2002 ;
Location in patent: Page 42 ;
反应条件
1H-imidazole in ethyl acetate; N,N-dimethyl-formamide T=0 - 20°C; Inert atmosphere; Reagent/catalyst;
参考文献
Stoner, Eric J.; Stengel, Peter J.; Cooper, Arthur J.
Organic Process Research and Development, 1999 , vol. 3, # 2 p. 145 - 148
反应条件
1: With 1H-imidazole in ethyl acetate; N,N-dimethyl-formamide T=0 - 25°C; 13 h; 2: With hydrogenchloride in water; ethyl acetate; N,N-dimethyl-formamide T=10 - 15°C;
参考文献
RANBAXY LABORATORIES LIMITED
Patent: WO2006/100552 A1, 2006 ;
Location in patent: Page/Page column 10-11 ;
