6-氯-9-(苯基甲基)-9H-嘌呤合成路线 （共 60 条）
反应条件
sodium hydride in N,N-dimethyl-formamide T=20°C;
参考文献
Kim, Bok Young; Ahn, Joong Bok; Lee, Hong Woo; Kang, Sung Kwon; Lee, Jung Hwa; Shin, Jae Soo; Ahn, Soon Kil; Hong, Chung Il; Yoon, Seung Soo
European Journal of Medicinal Chemistry, 2004 , vol. 39, # 5 p. 433 - 447
反应条件
potassium carbonate in N,N-dimethyl-formamide 22 h; Ambient temperature;
参考文献
Tetrahedron, , vol. 50, # 32 p. 9743 - 9756
反应条件
1: With hydrogenchloride in N,N-dimethyl-formamide 72 h; 2: With triethylamine in N,N-dimethyl-formamide
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2008/51404 A1, 2008 ;
Location in patent: Page/Page column 120 ;
反应条件
di-isopropyl azodicarboxylate; triphenylphosphine in tetrahydrofuran T=70°C; Mitsunobu coupling; 12 h;
参考文献
Lu, Weibing; Sengupta, Sujata; Petersen, Jeffrey L.; Akhmedov, Novruz G.; Shi, Xiaodong
Journal of Organic Chemistry, 2007 , vol. 72, # 13 p. 5012 - 5015
反应条件
tert-Butyl thionitrate; copper dichloride in tetrahydrofuran; acetonitrile T=25°C; 24 h;
参考文献
Kim, Yong Hae
Phosphorus, Sulfur and Silicon and the Related Elements, 1993 , vol. 74, # 1-4 p. 249 - 260
反应条件
sodium hydride in N,N-dimethyl-formamide; mineral oil T=20°C; 1 h;
参考文献
Organic Letters, , vol. 12, # 24 p. 5724 - 5727
反应条件
potassium carbonate in acetonitrile
参考文献
Angewandte Chemie, , vol. 105, # 12 p. 1822 - 1823
反应条件
thionyl chloride in N,N-dimethyl-formamide 1 h; Heating;
参考文献
Chattopadhyay, Gautam; Ray, Parlha Sinha
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013 , vol. 52, # 4 p. 546 - 552
反应条件
sodium hydride in N,N-dimethyl-formamide T=20°C; 24 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 38, # 2 p. 199 - 214
反应条件
potassium carbonate in dimethyl sulfoxide
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 12 p. 1768 - 1770
