6-氯-9-(苯基甲基)-9H-嘌呤合成路线 （共 60 条）
反应条件
in dimethylsulfoxide-d6 768 h;
参考文献
Kotek, Vladislav; Tobrman, Toma; Dvoak, Dalimil
Synthesis, 2012 , vol. 44, # 4 p. 610 - 618
反应条件
1.1: NaH / dimethylformamide / 1 h / 20 °C 1.2: dimethylformamide / 24 h / 20 °C 2.1: 28.0 g / TMSCl; tert-butyl nitrite; benzyltriethylammonium chloride / CH2Cl2 / 27 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 4 p. 632 - 638
反应条件
1.1: NaH / dimethylformamide / 1 h / 20 °C 1.2: dimethylformamide / 24 h / 20 °C 2.1: 28.0 g / TMSCl; tert-butyl nitrite; benzyltriethylammonium chloride / CH2Cl2 / 27 h / 20 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 4 p. 632 - 638
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran 16 h; Ambient temperature;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 40, # 4 p. 1039 - 1041
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran 10 h; Ambient temperature;
参考文献
Synthetic Communications, , vol. 23, # 9 p. 1295 - 1305
反应条件
1: 2 h / 180 °C 2: thionyl chloride / N,N-dimethyl-formamide / 1 h / |Heating View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 52, # 4 p. 546 - 552
反应条件
1.1: acetonitrile / 0.75 h / |Reflux 1.2: 0.75 h / |Reflux 2.1: 2 h / 180 °C 3.1: thionyl chloride / N,N-dimethyl-formamide / 1 h / |Heating View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 52, # 4 p. 546 - 552
反应条件
sodium hydroxide; tetrabutylammomium bromide in benzene 5 h; Ambient temperature;
参考文献
Ramzaeva, N. P.; Gol'dberg, Yu. Sh.; Lidak, M. Yu.; Alksnis, E. R.; Yure, M. V.; Gudrinietse, E. Ya.
Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 8.2 p. 1608 - 1611
Zhurnal Organicheskoi Khimii, 1989 , vol. 25, # 8 p. 1780 - 1783
反应条件
sodium azide in N,N-dimethyl-formamide T=20°C; Overall yield = 80 percent; Overall yield = 0.21 g;
参考文献
Chattopadhyay, Gautam; Ray, Parlha Sinha
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013 , vol. 52, # 4 p. 546 - 552
反应条件
ammonia in methanol T=90°C; 7 h;
参考文献
Laufer, Stefan A.; Domeyer, David M.; Scior, Thomas R. F.; Albrecht, Wolfgang; Hauser, Dominik R. J.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 3 p. 710 - 722
