6-氯-9-(苯基甲基)-9H-嘌呤合成路线 （共 60 条）
反应条件
triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide T=120°C; Sonogashira reaction; 7 h;
参考文献
Hocek, Michal; Stara, Irena G.; Stary, Ivo; Dvorakova, Hana
Collection of Czechoslovak Chemical Communications, 2002 , vol. 67, # 8 p. 1223 - 1235
反应条件
bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide T=75°C; Stille coupling; 2.5 h;
参考文献
Bakkestuen, Anne Kristin; Gundersen, Lise-Lotte; Langli, Geir; Liu, Fusheng; Nolsoe, Jens M.J.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 11 p. 1207 - 1210
反应条件
1: 70 percent / Et3N / Pd(PPh3)4; CuI / dimethylformamide / 7 h / 120 °C 2: 65 percent / NH3 / ethanol / 3 h / 20 °C View Scheme
参考文献
Hocek, Michal; Stara, Irena G.; Stary, Ivo; Dvorakova, Hana
Collection of Czechoslovak Chemical Communications, 2002 , vol. 67, # 8 p. 1223 - 1235
反应条件
hydrogenchloride in water Hydrolysis; 1 h; Heating;
参考文献
Nucleosides and Nucleotides, , vol. 18, # 4-5 p. 661 - 671
反应条件
1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 20 °C 1.2: 16 h / 60 °C 2.1: tetrakis(triphenylphosphine) palladium(0) / tetrahydrofuran / 16 h / 60 °C View Scheme
参考文献
Chemical Papers, , vol. 67, # 1 p. 3 - 8,6
反应条件
1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2 h / 20 °C / Inert atmosphere
2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C
View Scheme
参考文献
Xia, Ran; Xie, Ming-Sheng; Niu, Hong-Ying; Qu, Gui-Rong; Guo, Hai-Ming
Green Chemistry, 2014 , vol. 16, # 3 p. 1077 - 1081
反应条件
1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 2 h / 20 °C / Inert atmosphere
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Kotek, Vladislav; Chudikova, Nadezda; Tobrman, Tomas; Dvorak, Dalimil
Organic Letters, 2010 , vol. 12, # 24 p. 5724 - 5727
反应条件
1: hydrazine hydrate / ethanol / 2 h / |Reflux
2: copper(II) sulfate; water; water-d2; oxygen / 6 h / 80 °C / |Green chemistry
View Scheme
参考文献
Xia, Ran; Xie, Ming-Sheng; Niu, Hong-Ying; Qu, Gui-Rong; Guo, Hai-Ming
Green Chemistry, 2014 , vol. 16, # 3 p. 1077 - 1081
反应条件
potassium carbonate in dimethyl sulfoxide
T=20 - 80°C; Microwave irradiation;
参考文献
Guo, Hai-Ming; Mao, Zhi-Jie; Niu, Hong-Ying; Wang, Dong-Chao; Zhang, Gui-Sheng; Qu, Gui-Rong
Arkivoc, 2010 , vol. 2010, # 9 p. 300 - 307
反应条件
zinc dibromide; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=50°C; 0.5 h;
参考文献
Gundersen; Bakkestuen; Aasen; Overas; Rise
Tetrahedron, 1994 , vol. 50, # 32 p. 9743 - 9756
