6-氯-9-(苯基甲基)-9H-嘌呤合成路线 （共 60 条）
反应条件
1: 90.3 percent / 55percent aq. HI / 1.5 h / -5 °C
2: 6.4 percent / sodium bicarbonate, sodium thiosulfate / acetone / 1 h / Irradiation
View Scheme
参考文献
McKenzie, Thomas C.; Epstein, Joseph W.
Journal of Organic Chemistry, 1982 , vol. 47, # 25 p. 4881 - 4884
反应条件
sodium
T=100°C; 0.25 h; Microwave irradiation;
参考文献
Bliman, David; Pettersson, Mariell; Bood, Mattias; Grotli, Morten
Tetrahedron Letters, 2014 , vol. 55, # 18 p. 2929 - 2931
反应条件
N-chloro-succinimide in 1,2-dichloro-ethane
90 h; Heating;
参考文献
Nolsoe, Jens M. J.; Gundersen, Lise-Lotte; Rise, Frode
Acta Chemica Scandinavica, 1999 , vol. 53, # 5 p. 366 - 372
反应条件
hydrazine hydrate in ethanol
3 h; Reflux;
参考文献
Chattopadhyay, Gautam; Ray, Parlha Sinha
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013 , vol. 52, # 4 p. 546 - 552
反应条件
1: 1-iodomethyl acetate With chloro-trimethyl-silane; 1,1-dibromo ethane; zinc in tetrahydrofuran
T=0 - 5°C; 1 h;
2: 9-Bn-6-chloropurine With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran
T=20°C; Negishi reaction; 8 h;
参考文献
Silhar, Peter; Pohl, Radek; Votruba, Ivan; Hocek, Michal
Organic Letters, 2004 , vol. 6, # 19 p. 3225 - 3228
反应条件
1.1: zinc / tetrahydrofuran / 1 h / 10 - 15 °C
1.2: 81 percent / Pd(PPh3)4 / tetrahydrofuran / 8 h / 20 °C
2.1: 88 percent / MeONa / methanol / 20 °C
View Scheme
参考文献
Silhar, Peter; Pohl, Radek; Votruba, Ivan; Hocek, Michal
Organic Letters, 2004 , vol. 6, # 19 p. 3225 - 3228
反应条件
in N,N-dimethyl-formamide
T=180°C; Microwave irradiationInert atmosphere;
参考文献
Bliman, David; Pettersson, Mariell; Bood, Mattias; Grotli, Morten
Tetrahedron Letters, 2014 , vol. 55, # 18 p. 2929 - 2931
反应条件
hydrogenchloride
T=180°C; 0.0333333 h; Microwave irradiation;
参考文献
Cechova, Lucie; Jansa, Petr; Sala, Michal; Dracinsky, Martin; Holy, Antonin; Janeba, Zlatko
Tetrahedron, 2011 , vol. 67, # 5 p. 866 - 871
反应条件
potassium carbonate in acetonitrile
T=70°C; 10 h; Inert atmosphere;
参考文献
Kotek, Vladislav; Chudikova, Nadezda; Tobrman, Tomas; Dvorak, Dalimil
Organic Letters, 2010 , vol. 12, # 24 p. 5724 - 5727
反应条件
1: hydrazine hydrate / ethanol / 3 h / |Reflux
2: N,N-dimethyl-formamide / 2 h / 125 - 130 °C
View Scheme
参考文献
Chattopadhyay, Gautam; Ray, Parlha Sinha
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013 , vol. 52, # 4 p. 546 - 552
