[2-(羟基甲基)-1,3-苯并噻唑-6-基]乙酸合成路线 （共 4 条）
反应条件
1: 1.) 50percent KOH; 2.) conc. HCl / 1.) reflux, 80 h; 2.) 0 - 5 deg C 2: 65 percent / ethane-1,2-diol / 7 h / 80 - 85 °C 3: 1.) NH4OH; 2.) conc. HCl / 1.) 60 - 65 deg C, 12 h; 2.) 0 - 5 deg C View Scheme
参考文献
Mashraqui, Sabir H.; Nivalkar, Kishor R.
Tetrahedron Letters, 1997 , vol. 38, # 25 p. 4487 - 4488
反应条件
1: 65 percent / ethane-1,2-diol / 7 h / 80 - 85 °C 2: 1.) NH4OH; 2.) conc. HCl / 1.) 60 - 65 deg C, 12 h; 2.) 0 - 5 deg C View Scheme
参考文献
Mashraqui, Sabir H.; Nivalkar, Kishor R.
Tetrahedron Letters, 1997 , vol. 38, # 25 p. 4487 - 4488
反应条件
hydrogenchloride; ammonium hydroxide 1.) 60 - 65 deg C, 12 h; 2.) 0 - 5 deg C; Yield given. Multistep reaction;
参考文献
Mashraqui, Sabir H.; Nivalkar, Kishor R.
Tetrahedron Letters, 1997 , vol. 38, # 25 p. 4487 - 4488
反应条件
hydrogen bromide; acetic acid 10 h; Heating;
参考文献
Mashraqui, Sabir H.; Nivalkar, Kishor R.
Tetrahedron Letters, 1997 , vol. 38, # 25 p. 4487 - 4488
