tetrabutyl ammonium fluoride in tetrahydrofuran T=-78°C; 3 h;

1: 80 percent / potassium iodide; potassium carbonate / acetonitrile / 80 °C 2: 71 percent / 2,6-lutidine; tin(IV) chloride / toluene 3: 75 percent / acetic acid; hydrochloric acid / 65 - 70 °C View Scheme

1.1: 2,6-lutidine / SnCl4 / toluene / 0.33 h / 20 °C 1.2: toluene / 12 h / 100 °C 2.1: 37 g / TBAF / tetrahydrofuran / 2 h / 20 °C View Scheme