3-溴-5-羟基苯甲酸甲酯合成路线 （共 7 条）
反应条件
1: With sulfuric acid in water T=0°C; Cooling with ice; 2: With sodium nitrite in water T=0°C; 0.5 h; Cooling with iceReflux;
参考文献
Journal of the American Chemical Society, , vol. 135, # 46 p. 17408 - 17416
反应条件
Oxonereg; in acetone T=25°C; 0.133333 h;
参考文献
Tetrahedron Letters, , vol. 47, # 28 p. 4897 - 4901
反应条件
1: potassium acetate / PdCl2(dppf) / dimethylsulfoxide / 6 h / 80 °C 2: aq. Oxone / acetone / 0.13 h / 25 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 47, # 28 p. 4897 - 4901
反应条件
sulfuric acid 5 h; Reflux;
参考文献
Journal of Medicinal Chemistry, , vol. 56, # 8 p. 3217 - 3227
反应条件
1.1: iron; hydrogenchloride / methanol; water / |Reflux 2.1: sulfuric acid / water / 0 °C / |Cooling with ice 2.2: 0.5 h / 0 °C / |Cooling with ice; |Reflux View Scheme
参考文献
Journal of the American Chemical Society, , vol. 135, # 46 p. 17408 - 17416
反应条件
1.1: sulfuric acid; dibromoisocyanuric acid / 2 h / 20 °C 2.1: iron; hydrogenchloride / methanol; water / |Reflux 3.1: sulfuric acid / water / 0 °C / |Cooling with ice 3.2: 0.5 h / 0 °C / |Cooling with ice; |Reflux View Scheme
参考文献
Journal of the American Chemical Society, , vol. 135, # 46 p. 17408 - 17416
反应条件
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; potassium acetate in 1,4-dioxane T=90°C; Inert atmosphere;
参考文献
ALMIRALL, S.A.; ERRA SOLA, Montserrat; CARRASCAL RIERA, Marta; TALTAVULL MOLL, Joan; CATURLA JAVALOYES, Juan Francisco; BERNAL ANCHUELA, Francisco Javier; PAGES SANTACANA, Lluis Miquel; MIR CEPEDA, Marta; CASALS COLL, Gaspar; HERNANDEZ OLASAGARRE, Maria Begoña
Patent: WO2014/60432 A1, 2014 ;
Location in patent: Page/Page column 130; 131 ;
