1: 85 percent / TBAF / tetrahydrofuran / 16 h / Ambient temperature 2: 56 percent / DIBALH / tetrahydrofuran; hexane / 1.5 h / -78 °C 3: 79 percent / HCl / 6 h / Ambient temperature View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 94 percent / H₂O₂, LiOH / tetrahydrofuran; H₂O / 1 h / 0 &deg;C<br />2: 62 percent / Et₃N, DPPA / toluene / 12 h / Heating<br /> <br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '2804567', constants.ctx, '0')">diphenyl-phosphinic acid</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '635760', constants.ctx, '0')">toluene</a> <br />12&nbsp;h;&nbsp;&nbsp;Heating;&nbsp;<br /> &nbsp;