1: 56 percent / DIBALH / tetrahydrofuran; hexane / 1.5 h / -78 °C 2: 79 percent / HCl / 6 h / Ambient temperature View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3570522', constants.ctx, '0')">tetrabutyl ammonium fluoride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />16&nbsp;h;&nbsp;&nbsp;Ambient temperature;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 62 percent / Et₃N, DPPA / toluene / 12 h / Heating<br />2: 85 percent / TBAF / tetrahydrofuran / 16 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 94 percent / H₂O₂, LiOH / tetrahydrofuran; H₂O / 1 h / 0 &deg;C<br />2: 62 percent / Et₃N, DPPA / toluene / 12 h / Heating<br />3: 85 percent / TBAF / tetrahydrofuran / 16 h / Ambient temperature<br /> <br /> &nbsp;