3,4-二甲氧基-2-羟基苯甲醛合成路线 （共 35 条）
反应条件
aluminium trichloride in benzene 3 h; Heating;
参考文献
Magnus, Philip; Mitchell, Ian S.
Tetrahedron Letters, 1998 , vol. 39, # 50 p. 9131 - 9134
反应条件
1: With boron trichloride in dichloromethane T=0°C; 5 h; Inert atmosphere; 2: With water in dichloromethane
参考文献
US2012/130129 A1, ;
Page/Page column 12 ;
反应条件
in diethyl ether T=0°C; 1 h; Yields of byproduct given;
参考文献
Singh, Sheo Bux; Pettit, George R.
Journal of Organic Chemistry, 1989 , vol. 54, # 17 p. 4105 - 4114
反应条件
triethylamine; magnesium chloride in tetrahydrofuran Inert atmosphereReflux; regioselective reaction;
参考文献
Akselsen, yvind W.; Skattebol, Lars; Hansen, Trond Vidar
Tetrahedron Letters, 2009 , vol. 50, # 46 p. 6339 - 6341
反应条件
1: 65 percent / BnNEt3Br, NaOH / CH2Cl2; H2O / 0.17 h / 25 °C 2: 87 percent / NaIO4 / tetrahydrofuran; H2O 3: TMSOTf, 2,6-lutidine / CH2Cl2 / - 78 deg C, 30 min, RT, 1 h View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 50 p. 9131 - 9134
反应条件
1: 97 percent / DEAD, PPh3 / tetrahydrofuran / 0 °C 2: 95 percent / NaOH / methanol; H2O 3: 65 percent / BnNEt3Br, NaOH / CH2Cl2; H2O / 0.17 h / 25 °C 4: 87 percent / NaIO4 / tetrahydrofuran; H2O 5: TMSOTf, 2,6-lutidine / CH2Cl2 / - 78 deg C, 30 min, RT, 1 h View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 50 p. 9131 - 9134
反应条件
1: 87 percent / NaIO4 / tetrahydrofuran; H2O 2: TMSOTf, 2,6-lutidine / CH2Cl2 / - 78 deg C, 30 min, RT, 1 h View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 50 p. 9131 - 9134
反应条件
1: 95 percent / NaOH / methanol; H2O 2: 65 percent / BnNEt3Br, NaOH / CH2Cl2; H2O / 0.17 h / 25 °C 3: 87 percent / NaIO4 / tetrahydrofuran; H2O 4: TMSOTf, 2,6-lutidine / CH2Cl2 / - 78 deg C, 30 min, RT, 1 h View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 50 p. 9131 - 9134
反应条件
2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate in dichloromethane - 78 deg C, 30 min, RT, 1 h;
参考文献
Tetrahedron Letters, , vol. 39, # 50 p. 9131 - 9134
反应条件
sodium hydroxide; β-cyclodextrin T=60°C; 7 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 37, # 11 p. 3122 - 3124
