1: With iso-butyl nitrite; copper dichloride in acetonitrile modified Sandmeyer reaction; Heating; 2: With N-ethyl-N,N-diisopropylamine; trichlorophosphate in acetonitrile Heating;

iso-butyl nitrite; copper dichloride in acetonitrile modified Sandmeyer reaction; Heating;

2-iodo-pyridine; triphenylphosphine; zinc; palladium diacetate in N,N-dimethyl-formamide T=50°C;

triphenylphosphine; palladium diacetate in tetrahydrofuran Negishi coupling; Heating;