7-苄基-4-氯-5,6,7,8-四氢吡啶并[3,4-d]嘧啶合成路线 （共 5 条）
反应条件
1: With N-ethyl-N,N-diisopropylamine; trichlorophosphate in toluene T=100°C; 0.5 h; 2: With sodium hydrogencarbonate in water; toluene T=20°C; 1 h;
参考文献
WO2005/42537 A1, ;
Page/Page column 86 ;
WO 2005/042537 A1
反应条件
trichlorophosphate 4 h; Heating / reflux;
参考文献
WO2007/28022 A2, ;
Page/Page column 42 ;
反应条件
1: With sodium ethanolate in ethanol T=60°C; 2: With trichlorophosphate T=90°C; 3 h; Product distribution / selectivity;
参考文献
US2006/128710 A1, ;
Page/Page column 10; 14 ;
反应条件
in propan-1-ol; acetonitrile
T=80°C; Inert atmosphereLarge scale;
参考文献
Connolly, Terrence J.; Matchett, Michael; Sarma, Keshab
Organic Process Research and Development, 2005 , vol. 9, # 1 p. 80 - 87
反应条件
1: acetonitrile; propan-1-ol / 80 °C / |Inert atmosphere; |Large scale
2: palladium on activated charcoal; hydrogen / methanol / 2068.65 Torr / |Inert atmosphere
View Scheme
参考文献
Connolly, Terrence J.; Matchett, Michael; Sarma, Keshab
Organic Process Research and Development, 2005 , vol. 9, # 1 p. 80 - 87
