3-(4-甲氧基苯基)丙酸合成路线 （共 94 条）
反应条件
1: oxalyl chloride / CH2Cl2; dimethylformamide / 0.5 h / 20 °C
2: 183 mg / Et3N / CH2Cl2 / 0.33 h / 20 °C
3: 95 percent / PdCl2(PPh3)2 / toluene; tetrahydrofuran / 0.25 h / 20 °C
View Scheme
参考文献
Miyazaki, Tohru; Han-Ya, Yuki; Tokuyama, Hidetoshi; Fukuyama, Tohru
Synlett, 2004 , # 3 p. 477 - 480
反应条件
1: LiAlH4 / tetrahydrofuran
2: PBr3
3: BBr3 / CH2Cl2
View Scheme
参考文献
Tamiz, Amir P.; Whittemore, Edward R.; Woodward, Richard M.; Upasani, Ravindra B.; Keana, John F.W.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 11 p. 1619 - 1624
反应条件
1: thionyl chloride
2: 63 percent / diethyl ether
3: 90 percent / hydrazine hydrate / methanol / Heating
4: 38 percent / lead tetra-acetate / CH2Cl2 / 0.25 h / Ambient temperature
View Scheme
参考文献
Atkinson, Robert S.; Malpass, John R.; Woodthorpe, Katherine L.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , # 10 p. 2407 - 2412
反应条件
di-isopropyl azodicarboxylate in dichloromethane
T=40°C; Mitsunobu reaction; 2 h;
参考文献
Imura, Yumi; Shimojuh, Naoya; Kawano, Yuhta; Togo, Hideo
Tetrahedron, 2010 , vol. 66, # 19 p. 3421 - 3426
